Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides
SAR and the binding mode of a novel series of carboxamide influenza sialidase inhibitors related to GG167 have been investigated. A hitherto unobserved intramolecular salt bridge within the influenza sialidases accounts for the observed activity and selectivity.
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