Current Biology
Volume 4, Issue 7, July 1994, Pages 615-617
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SH3 Domains: Molecular ‘Velcro’1

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Abstract

SH3 domains are ubiquitous intracellular protein modules; structural and functional studies are revealing how they interact with their proline-rich ligands to promote the formation of specific protein aggregates.

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Many biological processes involve the formation of specific protein aggregates or complexes, a good example being the transduction of signals through the cytoplasm by receptors with tyrosine kinase activity. Receptor aggregation is initiated by ligands — usually hormones or growth factors — outside the cell; inside the cell, phosphorylation-mediated protein association is crucial to the transmission of signals

Acknowledgements

We thank MRC, SERC, Wellcome and Zeneca for support and the Ludwig Institute in London for valuable collaborations.

C.J. Morton and I.D. Campbell, Oxford Centre for Molecular Sciences and Department of Biochemistry, South Parks Road, Oxford OX1 3QY, UK.

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C.J. Morton and I.D. Campbell, Oxford Centre for Molecular Sciences and Department of Biochemistry, South Parks Road, Oxford OX1 3QY, UK.

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