Granulocyte clearance by apoptosis in the resolution ofinflammation

doi:10.1016/S1043-4682(05)80009-1

Seminars in Cell Biology

Volume 6, Issue 6, December 1995, Pages 385-393

https://doi.org/10.1016/S1043-4682(05)80009-1 Get rights and content

Abstract

It has recently been recognized that extravasated granulocytesundergo apoptosis or programmed cell death. This process controls the functional longevity of these cells and is exquisitely modulated by environmental inflammatory mediators. By contrast with necrosis, an alternative fate for granulocytes in tissues, during apoptosis the granulocyte membrane remains intact and potentially injurious granule contents are retained. The intact apoptotic cell is removed by macrophages utilizing novel surface recognition mechanisms which fail to trigger a pro-inflammatory macrophage response. The balance between granulocyte apoptosis and necrosis in inflamed tissues may be an important determinant of the degree of tissue injury, and further dissection of the mechanisms of granulocyte apoptosis and removal may lead to new therapeutic strategies in inflammatory disease.

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Granulocyte clearance by apoptosis in the resolution ofinflammation

Abstract

Int Rev Cytol

Adv Immunol

Cell

Immunol Today

Cell

Cell

Cell

Cell

Cell

Cell

Cell

Lancet

Kid Int

Immunol

FEBS Lett

Blood

Blood

J Biol Chem

Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes

Clin Sci

Fate of neutrophils

Peritoneal macrophages which phagocytose autologous poly morphonuclear leucocytes in guinea-pigs

Br J Exp Pathol

Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages

J Exp Med

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages

J Clin Invest

Apoptosis: a basic biological phenomenon with widespread implications in tissue kinetics

Br J Cancer

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

Nature

Apoptotic cell death in epithelial cells: Cleavage of DNA to 300 and/or 50 kilobase fragments prior to or in the absence of internucleosomal fragmentation

EMBO J

Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes

J Immunol

Social controls on cell survival and cell death

Nature

The Fas death factor

Science

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77

Nature

Mechanisms and functions of cell death

Annu Rev Cell Biol

Involvement of an ICE-like protease in Fas-mediated apoptosis

Nature

Bcl-2: an antidote to programmed cell death

Cancer Surveys

Bcl-2 and the regulation of programmed cell death

J Cell Biol

Bcl-2 heterodimerizes in vitro with a conserved homolog, Bax, that accelerates programmed cell death

Cell