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Evidence for preventive treatments in young patients at clinical high risk of psychosis: the need for context

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Cited by (12)

  • Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis

    2022, The Lancet Psychiatry
    Citation Excerpt :

    Current ARMS criteria include the presence of mild (attenuated) psychotic symptoms, full threshold but brief (limited and intermittent) psychotic symptoms, or familial risk along with substantial functional deterioration.16,17 Despite debates regarding the effectiveness, relative risks, and benefits of specific treatments,14,18–20 interventions do delay and potentially prevent transition to a full psychotic disorder.21,22 ARMS services have now expanded across five continents,23 with neurobiological and clinical research proceeding apace.

  • Has improved treatment contributed to the declining rate of transition to psychosis in ultra-high-risk cohorts?

    2022, Schizophrenia Research
    Citation Excerpt :

    This increased effectiveness of control/’treatment as usual’ conditions may have introduced a ceiling effect for finding additional benefit of specific trial interventions. It is also possible that the limitations of the statistical approach taken in these meta analyses (e.g., network meta analyses requiring a high number of head-to-head comparisons) may have contributed to their findings (Nelson et al., 2019; Nelson et al., 2018c). A number of limitations to the current study need to be recognised.

  • Preventive interventions for individuals at ultra high risk for psychosis: An updated and extended meta-analysis

    2021, Clinical Psychology Review
    Citation Excerpt :

    Both treatments are well accepted and used globally. There is concern that the findings, and especially their interpretation, from recent network meta-analyses of non-superiority have created the perception that current interventions are not effective (McGorry et al., 2020; McGorry, Mei, Hartmann, Yung, & Nelson, 2021; McGorry & Nelson, 2020; Nelson et al., 2020; Nelson, Amminger, & McGorry, 2018; Nelson, Amminger, Thompson, et al., 2020). Although superiority over other therapeutic options has not been demonstrated via NMA, which is not unexpected, pairwise meta-analyses have shown clear benefits in favor of CBT.

  • The Role of Psychopharmacology in Mental Health Prevention

    2022, Prevention in Mental Health: From Risk Management to Early Intervention
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