Trial DesignA randomized prospective multicenter trial for stroke prevention by prophylactic surgical closure of the left atrial appendage in patients undergoing bioprosthetic aortic valve surgery––LAA-CLOSURE trial protocol
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Funding: This work was supported by The Finnish Medical Foundation, Helsinki, Finland; the Finnish Foundation for Cardiovascular Research, Helsinki, Finland; State Clinical Research Fund (EVO) of Turku University Hospital, Turku, Finland; and with an unrestricted research grant Atricure ltd (Mason, OH, USA).
Author Disclosures: Tuomas Kiviniemi: lectures for Bayer, Boehringer Ingelheim, AstraZeneca and St. Jude Medical, Bristol-Myers Squibb-Pfizer, MSD; received research grants from The Finnish Medical Foundation, Helsinki, Finland; the Finnish Foundation for Cardiovascular Research; Clinical Research Fund (VTR) of Turku University Hospital, Turku, Finland, Finnish Cardiac Society. Member of advisory board for Boehringer Ingelheim, MSD. Anders Jeppsson: Lectures for Boehringer-Ingelheim, Consultancy fees from Xvivo Perfusion, Werfen, Boehringer-Ingelheim, Portola and LFB France. Research grants from the Swedish State (ALF), Swedish Heart Lung Foundation, Region Västra Götaland, Swedish Research Council.
Frank Halfwerk: No conflict of interest related to the present study. Outside this trial, Thoraxcentrum Twente has received institutional research grants from Abbott Vascular, Biotronik, Boston Scientific and Medtronic. Juha Hartikainen: research grants from EU 2020 Horizon, the Finnish Foundation for Cardiovascular Research, Clinical Research Fund (VTR) of Kuopio University Hospital, Kuopio, Finland; Lectures for; Cardiome AG, MSD and AstraZeneca. Member of the advisory boards for Amgen, Pfizer, MSD, AstraZeneca, Bayer and BMS. Markus Malmberg: travel grants and congress sponsorship (Abbott, Boston Lifesciences, Medtronic). Juhani Airaksinen: research grants from the Finnish Foundation for Cardiovascular Research, Clinical Research Fund (VTR) of Turku University Hospital, Turku, Finland; Lectures for Bayer, Cardiome AG and Boehringer Ingelheim, Member in the advisory boards for Bayer, Astra Zeneca, Bristol-Myers Squibb-Pfizer and Boston Scientific.
Gregory Lip: Consultant and speaker for BMS/Pfizer, Boehringer Ingelheim and Daiichi-Sankyo. No fees are received personally.