General Obstetrics and Gynecology: ObstetricsAdipose tissue from pregnant women with and without gestational diabetes mellitus: Insulin-sensitive but resistant to hyperosomolarity
Section snippets
Material and methods
The study cohort consisted of 16 pregnant women with normal glucose tolerance (NGT), 13 subjects with GDM, and 19 nonpregnant control subjects. Subjects were recruited on the morning of their elective abdominal surgery or elective lower uterine segment cesarean delivery (LUSCS). The pregnant women were all delivered at 37 to 40 weeks of gestation. Retrospectively, information was gathered regarding each pregnant subject's glucose tolerance status. The Australian Diabetes in Pregnancy Society
Results
Table I describes the characteristics of the subjects. The nonpregnant group was older than the pregnant group of subjects (42 ± 8 years old vs 33 ± 6 years old vs 33 ± 4 years old, nonpregnant vs NGT vs GDM. respectively; P < .001 compared with nonpregnant women). There was no difference in BMI between the groups with either the prepregnancy BMI or current BMI. Overall glycemia, as assessed by fructosamine, was comparable between the pregnant women with GDM and NGT.
Comment
The results of this study did not support the initial hypothesis that adipose tissue from pregnant women would demonstrate reduced insulin-stimulated glucose uptake compared with that from nonpregnant control subjects, nor the hypothesis that insulin-stimulated glucose uptake would be impaired in women with GDM compared with pregnant women with NGT. Rather, we found that basal and insulin-stimulated glucose uptake in both subcutaneous and omental adipose tissues are similar in pregnant and
Acknowledgments
We thank P. Imbeault (University of Ottawa, Canada) and E. Bellar (University of Queensland, Australia) for assistance with statistical analysis, the surgeons and obstetricians from the Princess Alexandra and Mater Mother's Hospitals, and especially to the women for their participation.
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Supported by Wellcome Senior Research Fellowship in Medical Science and Princess Alexandra Hospital Foundation (J.B.P.), a Wellcome International Travelling Fellowship (J.P.W.), and a NovoNordisk regional diabetes scheme grant and National Health and Medical Research Committee postgraduate medical research scholarship (A.W.R.).