Preventive cardiologyComparison of Waist Circumference Versus Body Mass Index in Diagnosing Metabolic Syndrome and Identifying Apparently Healthy Subjects at Increased Risk of Cardiovascular Disease
Section snippets
Methods
The study population consisted of 402 volunteers of European ancestry (227 women, 175 men) who had responded to advertisements for studies describing our research interest in the role of insulin resistance in human disease. The studies were performed at the General Clinical Research Center at Stanford University Hospital, Stanford, California. All subjects gave informed consent, and the protocols had been approved by the Stanford Human Subjects Committee.
Subjects were in apparent good health,
Results
Table 1 lists criteria for the diagnosis of MS according to the ATP III and IDF. Measurements of WC and BMI significantly (p <0.001) correlated in both men (r = 0.83) and women (r = 0.82). In addition, as shown in Figure 1, the relation between each index of adiposity and steady-state plasma glucose was very similar in men and women and was statistically significant (p <0.001).
To further evaluate the relation between insulin-mediated glucose uptake and BMI and WC, we performed logistic
Discussion
The existence of multiple definitions of MS led to several reports comparing the relative ability of these to determine the prevalence of the syndrome in various populations and/or the utility of each of the diagnoses to predict cardiovascular disease.11, 12, 13 However, little attention was given to comparing metabolic characteristics that result from classifying patients based on differences in the criteria for abdominal obesity used by the ATP III and IDF or the relation between abdominal
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This work was supported in part by research grants from the National Institutes of Health, Bethesda, Maryland (RR000070), and Stanford University School of Medicine Dean's Fellowship (MCR), Stanford, California.