Coronary artery diseaseCardiac Hemodynamics in Men Versus Women During Acute ST-Segment Elevation Myocardial Infarction
Section snippets
Methods
The present observational cohort study used data from a STEMI clinical registry that were collected from two South Australian teaching hospitals (the Queen Elizabeth and Lyell McEwin hospitals). These university teaching hospitals service the northwestern suburbs of Adelaide. From October 2005 to October 2010, 912 consecutive STEMI patients (n = 234 women, 26%) presented to the two hospitals and had extensive clinical data collected, including cardiovascular risk factors, medications, and STEMI
Results
From the 912 consecutive cases in the STEMI registry, hemodynamic data were available for 470 patients (n = 135 women, 15%). More than half of the hospital interventional cardiologists routinely performed RHC (68%) in the patients with acute STEMI they attended but only on selected patients by other cardiologists (32% RHC). Thus, the study cohort essentially represented consecutive patients treated by these interventional cardiologists. Moreover, compared with the overall cohort (n = 912), the
Discussion
The present study has provided important insights into the sex differences in clinical outcomes after acute STEMI, demonstrating that women have a greater PCWP than men. This was evident despite a similar infarct site and size, extent of coronary artery disease, and hospital-arrival clinical hemodynamic status. Although women with acute STEMI were more likely to be older and have hypertension, multivariate regression analysis confirmed that female sex was an independent predictor of PCWP, along
Disclosures
The authors have no conflicts of interest to disclose.
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