Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Volume 1811, Issue 12, December 2011, Pages 1011-1020
Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice
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open access
Graphical abstract
Highlights
► DGAT1 deficiency on an ApoE-null background reduces diet-induced atherosclerotic lesion formation. ► DGAT1 deficiency decreases cholesterol uptake and absorption in ApoE-null mice. ► Reduced macrophage migration and decreased aortic inflammation in ApoE-null mice lacking DGAT1. ► Increased cholesterol efflux from macrophages lacking DGAT1. ► Additional potential application of DGAT1 inhibitors with regard to attenuating atherosclerosis.
Abbreviations
ApoE
apolipoprotein E
DGAT
acyl-CoA:diacylglycerol acyltransferase
FA
fatty acids
FFA
free fatty acids
FC
free cholesterol
TC
total cholesterol
TG
triacylglycerol
WTD
western-type diet
Keywords
Atherosclerosis
Cholesterol absorption
Cholesterol efflux
Acyl-CoA:diacylglycerol acyltransferase 1
Inflammation
Apolipoprotein E knockout mice
Cited by (0)
- 1
Present address: National Human Genome Research Institute, 35 Convent Dr., Bethesda, MD 20892, USA.
- 2
Present address: Division of Pulmonary and Critical Care, University of Colorado Denver, Anschutz Medical Campus 12700, Denver, CO 80045, USA.
Copyright © 2011 Elsevier B.V.