Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1833, Issue 1, January 2013, Pages 33-39
Reviewp21-activated kinases and gastrointestinal cancer
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Highlights
► The p21-activated kinases (PAKs) are up-regulated in several human cancers. ► PAK overexpression is linked to tumour progression and resistance to therapy. ► PAK1 connects multiple signalling pathways important in colorectal cancer. ► PAKs are attractive targets for new therapies for gastrointestinal cancers.
Abbreviations
AID
auto-inhibitory domain
CDK5RAP3
CDK5 kinase regulatory subunit-associated protein 3
CRC
colorectal carcinoma
EGFR
epithelial growth factor receptor
GAP
GTPase-activating protein
HBV
hepatitis B virus
HBx
HBV X protein
HCC
hepatocellular carcinoma
PAK
p21-activated kinase
PBD
p21-binding domain
PSD
pseudosubstrate domain
Keywords
PAK
Signalling
Liver cancer
Pancreatic cancer
Gastric cancer
Colorectal cancer
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