Elsevier

Behavioural Brain Research

Volume 175, Issue 2, 15 December 2006, Pages 415-419
Behavioural Brain Research

Short communication
Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity

https://doi.org/10.1016/j.bbr.2006.08.034Get rights and content

Abstract

This study examined the density of dopamine transporter (DAT) and D2 receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice.

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Acknowledgments

This study was supported by grants from the National Health and Medical Research Council of Australia, and AstraZeneca, Mölndal, Sweden.

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