Halogenated analogs of 1′-acetoxychavicol acetate, Rev-export inhibitor from Alpinia galanga, designed from mechanism of action
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Rational design based on the mechanism of action disclosed the four halogenated analogs (20a–20d) as the more potent Rev-export inhibitors than 1′-acetoxychavicol acetate (1).
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Acknowledgments
We wish to thank Professor Minoru Yoshida in RIKEN Advanced Science Institute for giving the fission yeast S. pombe. This work was supported in part by Grants-in-Aid for Scientific Research (Grant No. 19590100) from the Ministry of Education, Science, Culture and Sports. The authors are grateful to the Shorai Foundation for Science and Technology for financial support.
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