Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis

https://doi.org/10.1016/j.bmcl.2012.02.053Get rights and content

Abstract

Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′-nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo-tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 14 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity.

Section snippets

Acknowledgments

P.K. is supported by The Thailand Research Fund (TRF) and the Center of Excellence on Environmental Health and Toxicology, Science & Technology Postgraduate Education and Research Development Office (PERDO), Ministry of Education. We thank Chulabhorn Research Centre, Institute of Molecular Biosciences, Mahidol University, for partial financial support.

References and notes (31)

  • G. Sbardella et al.

    Bioorg. Med. Chem. Lett.

    (2004)
  • Q. Meng et al.

    Bioorg. Med. Chem. Lett.

    (2009)
  • Q. Meng et al.

    Bioorg. Med. Chem. Lett.

    (2009)
  • S. Bollo et al.

    Bioorg. Med. Chem. Lett.

    (2011)
  • V. Mahiou et al.

    Phytochemistry

    (2000)
  • World Health Organization, Report: Global Tuberculosis Control. World Health Organization, Geneva, Switzerland,...
  • C.M. Kunin

    Ann. Intern. Med.

    (1993)
  • A. Koul et al.

    Nature

    (2011)
  • S.D. Lawn et al.

    Curr. Opin. HIV AIDS

    (2009)
  • N.A. Martinson et al.

    Proc. Am. Thorac. Soc.

    (2011)
  • S. Tyagi et al.

    Antimicrob. Agents Chemother.

    (2005)
  • World Health Organization. The Global Plan to Stop TB 2011–2015: Transforming the Fight Towards Elimination of...
  • Cited by (0)

    View full text