Cancer Cell
Volume 33, Issue 4, 9 April 2018, Pages 690-705.e9
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Article
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

https://doi.org/10.1016/j.ccell.2018.03.014Get rights and content
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Highlights

  • Integrated analysis finds molecular features characteristic of gynecologic tumors

  • Subtypes with high leukocyte infiltration, a marker for immune response, identified

  • Gene-lncRNA interaction network of ESR1, DKC1, and lncRNAs TERC, NEAT1, and TUG1 identified

  • Decision tree to group patients into clinically relevant prognostic subtypes proposed

Summary

We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories.

Keywords

gynecologic cancer
breast cancer
ovarian cancer
uterine cancer
cervical cancer
uterine carcinosarcoma
TCGA
The Cancer Genome Atlas
pan-gynecologic
omics

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These authors contributed equally

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