Cancer Cell
Volume 37, Issue 6, 8 June 2020, Pages 756-758
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p38 Kinase: A Key Target for Driving Potent T Cells for Adoptive Immunotherapy

https://doi.org/10.1016/j.ccell.2020.05.012Get rights and content
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In this issue of Cancer Cell, Gurusamy et al. use a CRISPR-Cas9 screening approach to demonstrate that deletion of p38 increases multiple phenotypic qualities of effective anti-tumor T cells. Preconditioning T cells with a p38 inhibitor enhances anti-tumor efficacy of adoptive immunotherapy.

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These authors contributed equally