Cancer Cell
Volume 39, Issue 7, 12 July 2021, Pages 885-888
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The role of exhaustion in CAR T cell therapy

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CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

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