Cancer Cell
Volume 25, Issue 1, 13 January 2014, Pages 9-11
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From Anecdote to Targeted Therapy: The Curious Case of Thalidomide in Multiple Myeloma

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Thalidomide and related drugs are key drugs for the treatment of multiple myeloma (MM). These agents bind to cereblon, a component of a ubiquitin ligase complex, altering the specificity of the complex to induce the ubiquitylation and degradation of Ikaros (IKZF1) and Aiolos (IKZF3), transcription factors essential for MM growth.

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