Cell
Volume 139, Issue 6, 11 December 2009, Pages 1051-1053
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Females Battle to Suppress Their Inner Male

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Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.

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