Original ArticleAlimentary TractPrevalence of a First-Degree Relative With Colorectal Cancer and Uptake of Screening Among Persons 40 to 54 Years Old
Section snippets
Study Design and Study Population
Data for the analyses were drawn from the Risk adapted Prevention Strategies (RaPS) for CRC study, which has been described in more detail elsewhere.11,12 In short, RaPS is a 2-phase, multicenter, cross-sectional study conducted within the German Cancer Consortium, with recruitment sites in 3 large German cities (Dresden, Munich, and Stuttgart). For phase 1 of the RaPS study, a random sample of 160,000 individuals in the age range of 40 to 54 years from the 3 cities was drawn from population
Results
Of 160,000 invited persons in the cities of Dresden, Munich, and Stuttgart, 12,489 people were not reached via regular mail (Figure 1). Of those who received the invitation letter, 30,766 people participated in the online questionnaire. After exclusion of incomplete (n = 1814) or highly implausible (n = 3) questionnaires and data from participants with discrepancies between self-reported sex and/or age with the obtained registry offices data (n = 238), a total of 28,711 participants could be
Discussion
Within the population-based multicenter RaPS study, we observed a prevalence of having a FH of CRC in a FDR of 9.4% among 28,711 women and men aged 40 to 54 years from 3 large cities in Germany. The observed increasing FH prevalences with increasing age were driven by steadily increasing incidence of a FH in affected relatives diagnosed after age 70, whereas prevalences for an affected FDR diagnosed at younger than age 70 were comparable among all age groups. Even though people with a FH of CRC
Acknowledgments
The authors especially thank all study participants. The authors also thank Dr Utz Benscheid, Isabel Lerch, Dr Katarina Cuk, Dr Katja Butterbach, Volker Herrmann, Bernd Rasemann, Katrin Kollaske, Jovana Radlovic, Ulrike Seifert, Miriam Hofmann, Helga Lex, Caroline Tetzner, and Bernd Borstel for their excellent technical assistance and their contributions in data collection, monitoring, and documentation; and Kai Ravesloot for help with programming the online questionnaire.
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Conflicts of interest The authors disclose no conflicts.
Funding Supported by the German Federal Ministry of Education and Research through the German Cancer Consortium and in part by grant 01GL 1712. Also supported in part by the Robert Bosch Stiftung Stuttgart, Stuttgart, Germany (S.I. and M.S.).