Chemistry & Biology
Volume 18, Issue 4, 22 April 2011, Pages 438-444
Brief CommunicationSupramolecular Templating in Kirromycin Biosynthesis: The Acyltransferase KirCII Loads Ethylmalonyl-CoA Extender onto a Specific ACP of the trans-AT PKS
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Graphical Abstract
Highlights
► The acyl transferase KirCII is essential for kirromycin biosynthesis ► KirCII is loading ethylmalonyl-CoA to a specific ACP of the kirromycin PKS ► Supramolecular templating - a new alternative for generating polyketide diversity
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