Elecsys® Total-Tau and Phospho-Tau (181P) CSF assays: Analytical performance of the novel, fully automated immunoassays for quantification of tau proteins in human cerebrospinal fluid
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Keywords
Alzheimer's disease
Biomarkers
CSF
Fully automated immunoassay
Phosphorylated tau
Total tau
Abbreviations
Aβ42
amyloid-β (1–42)
AD
Alzheimer's disease
ADNI
Alzheimer's Disease Neuroimaging Initiative
ANOVA
analysis of variance
CLSI
Clinical and Laboratory Standards Institute
CN
cognitively normal
CSF
cerebrospinal fluid
CV
coefficient of variation
ELISA
enzyme-linked immunosorbent assay
FDA
US Food and Drug Administration
HPLC
high-performance liquid chromatography
Ig
immunoglobulin
LC-MS/MS
liquid chromatography-tandem mass spectrometry
LoB
limit of blank
LoD
limit of detection
LoQ
limit of quantitation
MCI
mild cognitive impairment
MCS
mild cognitive symptoms
NC
normal cognition
NIST
National Institute of Standards and Technology
PET
positron emission tomography
pTau
phosphorylated 181P tau
QC
quality control
SCD
subjective cognitive decline
SD
standard deviation
SMC
significant memory concern
tTau
total tau
UPenn
University of Pennsylvania
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© 2019 Roche Diagnostics International Ltd. Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists.