Current Biology
Volume 26, Issue 23, 5 December 2016, Pages R1242-R1245
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Chromosome Segregation: Reconstituting the Kinetochore

https://doi.org/10.1016/j.cub.2016.09.051Get rights and content
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Summary

Faithful chromosome segregation is accomplished by attachment of chromosomes to spindle microtubules using the kinetochore. In a major step forward in understanding the functional and structural complexity of kinetochores, a 21-subunit human centromere – kinetochore complex has been reconstituted entirely from purified components, recreating the connection between DNA and microtubule.

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