Developmental Cell
Volume 33, Issue 3, 4 May 2015, Pages 243-244
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Mitotic Spindle Orientation: Semaphorin-Plexin Signaling Flags the Way

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The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney development and repair.

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