NMR-determined lipoprotein subclass profile predicts type 2 diabetes☆,☆☆
Section snippets
Subjects
The Melbourne Collaborative Cohort Study (MCCS) was established to study prospectively cancer and other lifestyle related diseases [11]. The MCCS recruited 17,049 males and 24,479 females, aged between 27 and 75 years at baseline, 99.3% of whom were aged 40–69 years. The study participants were recruited from the Melbourne metropolitan area from 1990 to 1994 via the Electoral Rolls, advertisements and community announcements in local media. Southern European migrants to Australia were
Subject characteristics
Data are available for 59 cases (57%) and 754 controls (94%). The only significant difference between people with NMR data and those without was that the controls with NMR data had a median age 5 years less than those without data. No differences by inclusion status were observed for BMI, insulin or conventional lipids within cases or controls.
Southern European migrants were over-represented among people who developed diabetes, who were also older, had higher fasting glucose and were more obese
Discussion
Our results are consistent with the IRAS study, showing atherogenic lipoprotein abnormalities in people who subsequently developed diabetes, and extend the findings to a group that were not deliberately selected for a high diabetes risk. Concentration of large VLDL particles and HDL particle size predicted diabetes incidence. For both, the associations were independent of non-lipid risk factors, but neither improved diabetes prediction beyond conventional triglyceride concentration adjusting
Conflict of interest statement
None.
Acknowledgements
This study was made possible by the contribution of many people, including the original investigators and the diligent team who recruited the participants and completed follow-up. We would like to express our gratitude to the many thousands of Melbourne residents who continue to participate in the study. We would particularly like to acknowledge Dr. Jim Otvos for the analysis of the NMR lipoprotein profiles.
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2012, MaturitasCitation Excerpt :Body mass index (BMI) (weight/height2, kg/m2) was calculated. Serum glucose was measured from fasting blood samples by routine assays using a Kodak Ektachem analyzer (Rochester, NY, USA) [17] at MCCS inception between 1990 and 1994. Self-reported physician-diagnosed diabetes was recorded by using a questionnaire at MCCS inception (1990–4) and baseline MRI (2003–4).
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Related data was previously presented at the Australasian Epidemiological Association Annual Conference, September 18–19, 2006, University of Melbourne, Melbourne, Australia.
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This work was funded by VicHealth, The Cancer Council Victoria and the National Health and Medical Research Council (Grant Ids 124317, 126402, 126403, 180705, 180706, 194327, 209057, 251533).