NotesAn evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis☆,☆☆
Section snippets
Acknowledgment
The authors would like to thank Dr Ivan Bastian for kindly reviewing the manuscript.
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2021, New Microbes and New InfectionsPerformance of Xpert MTB/RIF Ultra assay on respiratory and extra-respiratory samples in a high-resource setting with a low tuberculosis prevalence
2021, Diagnostic Microbiology and Infectious DiseaseCitation Excerpt :The remaining Xpert-positive, culture-negative samples (33.3%) belong to patients with ancient history of prior tuberculosis treatment. Thirteen samples (1 nonrespiratory and 12 respiratory) were culture-positive for nontuberculous mycobacteria (NTM); Mycobacterium avium complex (Williamson et al., 2012) and Mycobacterium abscessus (WHO 2013). No cross-reactivity was observed in any of the 13 nontuberculous culture-positive samples.
Discordant line probe genotypic testing vs culture-based drug susceptibility phenotypic testing in TB endemic KwaZulu-Natal: Impact on bedside clinical decision making
2020, Journal of Clinical Tuberculosis and Other Mycobacterial DiseasesCitation Excerpt :An additional study demonstrated 100% sensitivity and specificity for detecting Mtb using the GeneXpert® MTB/RIF, with culture as the gold standard. However, the assay incorrectly assigned RIF resistance in 4/13 (31%) of cases [20]. Furthermore, in a Myanmar study, repeating the GeneXpert® MTB/RIF assay was required in order to compare the result with other available tests, particularly in results reported as “MTB detected very low, RIF resistance detected' [21].
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Funding: This study was supported by internal funding.
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Conflicts of interests: None for all authors.