Elsevier

Drug Discovery Today

Volume 17, Issues 17–18, September 2012, Pages 1039-1043
Drug Discovery Today

Review
Post screen
Viral targets of acylguanidines

https://doi.org/10.1016/j.drudis.2012.05.002Get rights and content

Acylguanidines are a new class of antiviral compounds with the unique ability to target both RNA polymerase and transmembrane proteins of viruses from different families. Importantly, they inhibit proteins which are not targeted by existing antiviral therapies, for example, Vpu of HIV type 1, p7 of hepatitis C virus, E of severe acute respiratory syndrome coronavirus and RNA-dependent RNA polymerase of coxsackievirus B3. BIT225, developed by Biotron Limited, is the first acylguanidine in clinical trials against HIV type 1 and hepatitis C virus. In this article we focus on the mechanisms of inhibition of viral proteins by acylguanidines.

Highlights

► Acylguanidines are a new class of antiviral compounds, targeting diverse proteins of viruses from different families. ► BIT225 is the first acylguanidine in clinical trials against human immunodeficiency virus type 1 and hepatitis C virus. ► This review focuses on the mechanisms of inhibition of viral proteins by acylguanidines.

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