Research PaperSalmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue
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Abbreviations
STY
Salmonella Typhi
STM
Salmonella Typhimurium
M cells
Microfold cells
CFU
colony forming units
LB
Luria Burtoni broth
DMEM
Dulbecco's Modified Eagle Medium
PBS
phosphate buffered saline
DTT
dithiothreitol
EDTA
ethylenediaminetetraacetic acid
ISC
intestinal stem cell
DAPT
N-[2S-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-1,1-dimethylethyl ester-glycine
qPCR
quantitative reverse transcriptase polymerase chain reaction
FITC
fluorescein isothiocyanate
TEER
trans-epithelial electrical resistance
RNA
ribonucleic acid
LDH
lactate dehydrogenase
H&E
hematoxylin and eosin
PAS
periodic acid Schiff
TEM
transmission electron microscopy
IL
interleukin
Keywords
Typhoid fever
Salmonella
Snapwell™ system
Human tissue
Terminal ileum
Immune system
Innate immunity
Immune evasion
Host-pathogen interaction
Vaccine development
Intestinal organoids
Organoid monolayer
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© 2018 The Authors. Published by Elsevier B.V.