Conclusions
The two pumps have markedly different effects on hemostasis. The HeartWare causes hyperactivation of the coagulation system compared to the Jarvik. Accordingly, HeartWare patients usually need both anticoagulant and antiplatelet drugs, while Jarvik patients are usually managed only with anticoagulation.
TEST | POSTOP. DAY | HVAD | JARVIK | P |
PLATELETS | 7 | 241,4±113,9 | 114,4±53,5 | 0,01 |
| 14 | 457,7±109,1 | 119,2±70,14 | < 0,0001 |
| 21 | 385,2±75,8 | 140,7±83,9 | 0,0002 |
| 28 | 326,5±7,8 | 168,9±81,3 | 0,03 |
| 60 | 353±102,6 | 166,1±77,9 | 0,002 |
| 135 | 292±99 | 180,1±90 | 0,17 |
INTEM MCF | 7 | 68,1±5,2 | 61,2±2 | 0,007 |
| 14 | 73,8±7,3 | 64,4±3,2 | 0,0104 |
| 21 | 77,5±3,2 | 58,2±6,4 | 0,0004 |
| 28 | 76,1± 5,2 | 53,4±8,7 | < 0,0001 |
EXTEM MCF | 7 | 67,8±4,9 | 60±3,2 | 0,004 |
| 14 | 71,9±5,5 | 63,4±6 | 0,02 |
| 21 | 78±4 | 60,4±2,4 | < 0,0001 |
| 28 | 75,5±6,9 | 54,2±4,2 | 0,0001 |
FIBTEM MCF | 7 | 32,5±4,5 | 28±2,4 | 0,03 |
| 14 | 36,9±8,1 | 28±4,1 | 0,02 |
| 21 | 41,5±13,1 | 30,6±6,8 | 0,09 |
| 28 | 35,4±26,2 | 19,8±10,4 | 0,25 |
TRAP | 7 | 68,2±16,7 | 30,3±17,2 | 0,005 |
| 14 | 86±20,7 | 53,2±28,6 | 0,05 |
| 21 | 99,9±37,7 | 53±1,2 | 0,04 |
| 28 | 108,1 ± 21,4 | 51,2±1,5 | 0,01 |
COL | 7 | 37±9,6 | 16,6±9,6 | 0,004 |
| 14 | 35,8±18 | 29,3±20,8 | 0,64 |
| 21 | 34,8±3,9 | 17±8,5 | 0,01 |
| 28 | 40,2±12,3 | 15±0,8 | 0,02 |