Case ReportCutaneous Microangiopathic Thrombosis Complicated by Pyoderma Gangrenosum in Post-Cardiac Surgery Heparin-Induced Thrombocytopaenia
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Discussion
Heparin is a hetereogenous mixture of linear chain sulphated polyanionic glycosaminoglycans. It exhibits its anticoagulant properties by binding to factor X, which participates in the conversion of prothrombin to thrombin. Thrombin converts fibrinogen to fibrin in the final pathway of the coagulation cascade.
Heparin induced thrombocytopaenia is a clinicopathological syndrome characterised by pathogenic antibodies of immunoglobulin G class against neoepitopes on multimolecular complexes of PF4
Acknowledgement
We thank Dr. Moira J. Finlay for the preparation of the pathology slides.
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