ReviewApplication of Clinical Databases to Contemporary Cardiac Surgery Practice: Where are We now?
Section snippets
Background
Whilst prospective and well-conducted randomised controlled trials (RCTs) are regarded as the highest level of research evidence in clinical medicine they often cannot be performed due to ethical, financial or practical reasons [1], [2]. This is particularly true in surgery where only 20-30% of primary treatment interventions are supported by randomised evidence [3]. For thoracic surgery only 14% of treatments are supported by randomised evidence [4]. Consequently, the effects of new devices
Advantages of Clinical Databases
The research utility of large databases is indisputable. One particular advantage is the ready availability of data on a large patient sample. This generally represents a larger proportion of the actual patient population and subsequently reduces sampling error and improves external validity [14]. Large databases also capture data on patients with rare diseases or those undergoing an infrequently performed procedure. Often, in clinical medicine, RCTs cannot be performed because low disease
Disadvantages for Clinical Databases
Despite their utility, databases have several disadvantages. Firstly, they are subject to treatment bias. The observed treatments were not randomly assigned, but rather the decisions were made based on patient, physician and institutional characteristics and preferences. Procedural selection is problematic as it confounds direct comparisons between groups. For research studies, several statistical techniques are employed to improve the ability to reduce this confounding and to help establish
Clinical Databases in Current Cardiothoracic Surgery Practice
Clinical databases capturing data on patients undergoing cardiothoracic surgery have been present for several decades. The largest, and arguably, most robust, cardiac surgery database is the Society of Thoracic Surgery (STS) Adult Cardiac Surgery Database (ACSD) from the United States which was established in 1989. The dataset has unique records on more than five million patients and represents 95% of programs in the United States [32]. The latest STS-ACSD edition collects information on >600
Future Endeavours
Cardiac surgery has increasingly used databases in clinical practice over the last 20 years. Moreover, clinical databases have been refined and improved through the process of continuous quality improvement. Nevertheless, there is considerable room for improvement. Many databases have not been linked to provide access to long-term survival and those that do often lack data on the cause of mortality. Moreover, angiographic follow-up is absent in all large clinical databases. The possible
Conclusions
Clinical databases are important for the purposes of clinical governance, quality control and research, among others. They have facilitated an increased understanding of the impact of cardiac surgery on patient outcomes. Important findings regarding the incidence or prevalence of cardiac risk factors in a population, disease and procedure-specific mortality, volume-outcome relationships, national trends, disparities in healthcare delivery, and other important insights will continue to be
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