286 Anthracycline Chemotherapy is not associated with Reductions in Right-Ventricular or Left Atrial Strain in Early-Stage Breast Cancer Patients

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Background

Anthracycline chemotherapy (AC) is a commonly used breast cancer treatment which detrimentally impacts LV systolic function. Short term follow-up focuses on LVEF and LVGLS, however its effects on right-ventricular free wall strain (RVFWS) and left atrial (LAS) strain are unknown.

Hypothesis

Short term effects of AC treatment will primarily affect LV systolic function.

Methods

Work was part of a larger trial assessing exercise training throughout AC. After excluding 2 participants with suboptimal images, females (n=28, 51±8 years) who were randomised to the usual care control arm underwent TTE prior to and 4-weeks following AC Rx (3-4 months). Speckle tracking imaging was performed offline by a single reader using EchoPac V20.1. LAS was the LA Reservoir peak with RVFWS the average of the basal, mid and apical segments. Data were assessed using generalized linear

Results

There were no significant changes in LAS (-0.9% [-3.3, 5.1], p=0.67), or RVFWS [-0.7% (-3.2, 1.7), p=0.56] following AC. In contrast, there was a decrease in both LVEF (-2.6% [-4.1, -1.0], p=0.001) and LVGLS (1.3% [0.6, 2.0], p=0.001).

Conclusion

In women with early-stage BC, preliminary evidence indicates AC is not associated with impairment in novel indices of RV and LA deformation, suggesting short term effects of AC may be better measured by approaches focused on LV function.

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