High-resolution allele frequencies for NGS based HLA-A, B, C, DQB1 and DRB1 typing of 23,595 bone marrow donors recruited for the Polish central potential unrelated bone marrow donor registry

doi:10.1016/j.humimm.2019.12.005

Human Immunology

Volume 81, Issues 2–3, February–March 2020, Pages 49-51

https://doi.org/10.1016/j.humimm.2019.12.005 Get rights and content

Abstract

Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopoietic stem cell transplantation. The donors were recruited for registry and not for any other purpose including controls in a disease association study. The population sample was collected in various regions of Poland including all voivodships. The data regarding the degree of relatedness among individuals in the sample were not collected. Typings were supported by public funds as a part of the Polish National Program for Transplant Medicine Development. HLA frequency data are available in the Allele Frequencies Net Database.

Section snippets

Acknowledgments

Potential bone marrow donor high-resolution HLA typing was supported by the Polish National Program for Transplant Medicine Development of the Polish Ministry of Health. We also would like to thank all Polish Donor Centers for their commitment and effort to recruit donors.

References (11)

E. Santos et al.
Allele Frequencies Net Database: improvements for storage of individual genotypes and analysis of existing data
Hum. Immunol.
(2016)
A.H. Schmidt et al.
High-resolution human leukocyte antigen allele and haplotype frequencies of the Polish population based on 20,653 stem cell donors
Hum. Immunol.
(2011)
E.L. van Dijk et al.
Ten years of next-generation sequencing technology
Trends Genet.
(2014)
R. Ceppellini et al.
The estimation of gene frequencies in a random-mating population
Ann. Hum. Genet.
(1955)
A.P. Dempster et al.
Maximum likelihood from incomplete data via the EM algorithm
J. R. Stat. Soc.
(1977)

There are more references available in the full text version of this article.

Cited by (0)

View full text

Short population reportHigh-resolution allele frequencies for NGS based HLA-A, B, C, DQB1 and DRB1 typing of 23,595 bone marrow donors recruited for the Polish central potential unrelated bone marrow donor registry

Abstract

Section snippets

Acknowledgments

Hum. Immunol.

Hum. Immunol.

Trends Genet.

The estimation of gene frequencies in a random-mating population

Ann. Hum. Genet.

Maximum likelihood from incomplete data via the EM algorithm

J. R. Stat. Soc.

Short population report
High-resolution allele frequencies for NGS based HLA-A, B, C, DQB1 and DRB1 typing of 23,595 bone marrow donors recruited for the Polish central potential unrelated bone marrow donor registry