Elsevier

IJC Heart & Vasculature

Volume 43, December 2022, 101139
IJC Heart & Vasculature

Prognostic association of plasma NT-proBNP levels in patients with microvascular angina -A report from the international cohort study by COVADIS-

https://doi.org/10.1016/j.ijcha.2022.101139Get rights and content
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Highlights

  • Plasma NT-proBNP levels may be a new prognostic biomarker of microvascular angina.

Abstract

Backgroud

The aim of this study was to assess the prognostic association of plasma levels of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) with clinical outcomes of patients with microvascular angina (MVA).

Methods

In this international prospective cohort study of MVA by the Coronary Vasomotor Disorders International Study (COVADIS) group, we examined the association between plasma NT-proBNP levels and the incidence of major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and hospitalization due to heart failure or unstable angina.

Results

We examined a total of 226 MVA patients (M/F 66/160, 61.9 ± 10.2 [SD] yrs.) with both plasma NT-proBNP levels and echocardiography data available at the time of enrolment. The median level of NT-proBNP level was 94 pg/ml, while mean left ventricular ejection fraction was 69.2 ± 10.9 % and E/e’ 10.7 ± 5.2. During follow-up period of a median of 365 days (IQR 365–482), 29 MACEs occurred. Receiver-operating characteristics curve analysis identified plasma NT-proBNP level of 78 pg/ml as the optimal cut-off value. Multivariable logistic regression analysis revealed that plasma NT-proBNP level ≥ 78 pg/ml significantly correlated with the incidence of MACE (odds ratio (OR) [95 % confidence interval (CI)] 3.11[1.14–8.49], P = 0.001). Accordingly, Kaplan-Meier survival analysis showed a significantly worse prognosis in the group with NT-proBNP ≥ 78 (log-rank test, P < 0.03). Finally, a significant positive correlation was observed between plasma NT-proBNP levels and E/e’ (R = 0.445, P < 0.0001).

Conclusions

These results indicate that plasma NT-proBNP levels may represent a novel prognostic biomarker for MVA patients.

Keywords

Microvascular angina
Brain natriuretic peptides
NT-proBNP
Prognosis

Cited by (0)

1

Current address: Graduate School, International University of Health and Welfare, 4-3 Kozunomori, Narita 286-8686, Japan.

2

This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.