AMA1 is thought to bind a parasite-encoded receptor complex in the host cell.
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This appears to be a universal invasion mechanism for apicomplexan parasites.
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New findings suggest that AMA1 may in fact not be essential for this process.
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We offer an alternative interpretation of these findings.
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We conclude that the role of AMA1 cannot yet be refuted.
Abstract
Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a ‘moving junction’ that provides a stable anchoring point through which the parasite invades host cells. The composition of the moving junction, particularly the presence of the protein Apical Membrane Antigen 1 (AMA1), has recently been the subject of some controversy. In this commentary we review findings that led to the current model of the moving junction complex and dissect the major conflicts to determine whether a substantial reassessment of the role of AMA1 is justified.
