Trends in Immunology
Volume 42, Issue 4, April 2021, Pages 273-275
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When Eating Becomes a Pain in the Gut

https://doi.org/10.1016/j.it.2021.02.008Get rights and content

Irritable bowel syndrome often appears following gastrointestinal infection and is marked by diarrhea, dysbiosis, fever, and intestinal pain following eating. A recent study by Aguilera-Lizarraga et al. now demonstrates that a breakdown in intestinal immunotolerance sparks an inflammatory response to typically tolerated food antigens and causes visceral pain.

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Acknowledgments

This work was funded by the National Health and Medical Research Foundation (Australia) and a University of Queensland Grant (G.T.B.).

Declaration of Interests

The authors declare no conflicts of interest.

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