Letter to the editor
Rotavirus vaccine induced diarrhea in a child with severe combined immune deficiency

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    Four of 15 infants with SCID treated by one of the authors (L.K.) at her institution required hospitalization in a pediatric intensive care unit for 2-3 weeks prior to transplant. Our estimates of avoided costs may also be conservative because we did not model the avoided costs of treating infections that can result from administering live virus vaccinations to babies with impaired immune systems.53,54 Higher cost estimates for infants with late-diagnosed SCID would make NBS appear more cost-effective (Figures 1 and 2).

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N.W.C. and C.D.K. were supported by the National Health and Medical Research Council Australia with a PhD Postgraduate Public Health Scholarship (437031) and an R. D. Wright Fellowship (334364), respectively.

Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

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