Mechanisms of allergy/immunologyProfilin-mediated food-induced allergic reactions are associated with oral epithelial remodeling
Graphical abstract
Section snippets
Patients
Thirty-eight patients (18-58 years old) with a clinical history of suspected food allergies and 6 nonallergic subjects were included in the study. The patients were studied in the allergy departments of 4 hospitals: Hospital Universitario de La Princesa (Madrid, Spain), Hospital Universitario Clinico San Carlos (Madrid, Spain), Hospital HM Sanchinarro (Madrid, Spain), and Hospital Virgen del Puerto de Plasencia (Cáceres, Spain). All patients were subjected to a thorough interview to establish
Patients with severe profilin allergy show epithelial acanthosis, higher collagen fiber deposition, and increased angiogenesis in the oral mucosa
We aimed to analyze whether the oral mucosal barrier might be compromised, thus potentially facilitating access to the immunologic system of profilin and accounting for increased sensitivity to profilin. Hematoxylin and eosin staining, together with blind evaluation by 2 independent pathologists (Fig 1, A), showed significant thickening of the epithelium in the mild and severe allergy groups compared with nonallergic subjects (Fig 1, B). This epithelial deformation is called acanthosis, a
Discussion
Several lines of evidence show that the interaction between epithelial and immune cells in the mucosa is critical in the onset and maintenance of allergic inflammation.23 An intact functional mucosal barrier is considered crucial in the maintenance of airway homeostasis because it protects the host immune system from exposure to allergens and noxious environmental triggers.24 Epithelial cells in the mucosa, which were initially thought to be just inert barriers, are now considered part of the
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2020, Molecular ImmunologyCitation Excerpt :Profilins are relevant allergens in pollen, plant foods, and latex allergies. A proportion of patients sensitized to profilin present both respiratory and food allergies, especially in areas of high exposure to grass or some tree pollens (Rosace et al., 2019). Profilins are a family of highly conserved proteins present in all eukaryotic cells.
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Supported by ISCIII (project nos. PI16/00249 and PI15/02256) by ISCIII, which was cofounded by FEDER, for the thematic network and cooperative research centers ARADyAL (RD16/0006/0015 and RD16/0006/0009). D.R. was supported by FPI-CEU predoctoral fellowships.
Disclosure of potential conflict of interest: M. Fernandez-Rivas received grants from the European Commission and the Spanish Government (ISCIII MINECO, grant no. P116/00249; ARADyAL, RD16/0006/099) and received consultant and personal support fees from Aimmune; personal fees from DBV (DSMV Member), Schrieber Foods, and Allergy Therapeutics; and meeting organization and speakers' fees from the Fundacion SEAICySMCL. D. Barber received grants from Instituto de Salud Carlos III and personal fees from ALK-Abelló and Aimmune outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest.