Rhinitis, sinusitis, and ocular allergyProtein arginine methyltransferase 1 contributes to the development of allergic rhinitis by promoting the production of epithelial-derived cytokines
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Graphical abstract
Key words
PRMT1
allergic rhinitis (AR)
epithelial cytokines
MAPKs
house dust mite (HDM)
Abbreviations used
ADMA
Asymmetric dimethylarginine
AIPI
Antigen-induced pulmonary inflammation
AMI-1
Arginine N-methyltransferase inhibitor-1
AR
Allergic rhinitis
COPD
Chronic obstructive pulmonary disease
COX2
Cyclooxygenase-2
HDM
House dust mite
MAPK
Mitogen-activated protein kinase
NAL
Nasal lavage
NF-κB
Nuclear factor kappa B
PRMT
Protein arginine methyltransferase
PRMT1+/−
PRMT1-haploinsufficient
TSLP
Thymic stromal lymphopoietin
WT
Wild-type
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∗Sang Chul Park, MD, PhD, is currently at the Department of Otorhinolaryngology-Head and Neck Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
This research was supported by the Global Research Lab Program (grant no. 2016K1A1A2910779) and the Mid-Career Researcher Program (grant no. 2018R1A2B3004143) of the National Research Foundation of Korea funded by the Ministry of Science and Information and Communication Technologies.
Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.
© 2021 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.