Autistic and schizotypal traits and global functioning in bipolar I disorder
Introduction
Bipolar disorder (BD) is a major affective disorder characterised by chronically recurring episodes of mania (or hypomania) and depression, which in their severe forms may present with psychotic symptoms, such as hallucinations or delusions (Weissman et al., 1996). This complex condition is often exacerbated by the presence of one or more comorbid conditions, in addition to a number of clinical factors such long duration of illness (Altamura et al., 2010, Altamura et al., 2015). While BD, schizophrenia spectrum disorders (SSD) and autism spectrum disorders (ASD) are considered distinct conditions, there is evidence for an overlap between BD and SSD (Altamura et al., 2014, Carroll and Owen, 2009, Moller, 2003), as well as between ASD and BD (Carroll and Owen, 2009, Stahlberg et al., 2004). Indeed, BD has a number of genetic, symptomatological and epidemiological overlaps with SSD (Laursen et al., 2009, Lichtenstein et al., 2009, Murray et al., 2004), and psychosis has been recognised as an important dimension in the psychopathology of BD (van Os and Kapur, 2009). In addition, schizotypy, which encompasses a set of personality traits that reflect subclinical expression of schizophrenia (Ettinger et al., 2015), is recognised as genetically related to SSD and is considered an endophenotype common to both SSD and BD (Ettinger et al., 2014, Mahon et al., 2013, Schurhoff et al., 2005). Schizotypy has been reported at elevated rates in individuals with BD compared to healthy controls, although this was conducted in a relatively small BD sample (N=92) (Heron et al., 2003).
Furthermore, there is growing evidence of an association between ASD and BD (Cross-Disorder Group of the Psychiatric Genomics, 2013; Vannucchi et al., 2014). ASD is defined by its cardinal impairments in social interaction, language and communication, and restricted behaviour and interests. To date, the majority of reports of ASD-BD comorbidity are in ASD samples, with prevalences ranging from 6% to 21.4% (Vannucchi et al., 2014). Only two studies have assessed ASD in BD samples: in youths (aged 7–17 years, N=157), 30% met diagnostic criteria for ASD (Joshi et al., 2013); and in a small sample of adults (N=56), 50% had high levels of autistic traits as measured with the Social Responsiveness Scale (Matsuo et al., 2015). Thus, the extant literature reporting the expression of autistic or schizotypal traits in BD has been limited by small samples, and requires replication in large, well-characterised, adult samples of BD.
The interplay between BD, SSD and ASD or expression of their traits may have significant consequences on global functioning in patients with BD. Global functioning, a measure of illness severity, provides an overall picture of an individual's combined psychological, social and occupational functioning, such as how adaptive the patient is in dealing with social and interpersonal problems (Endicott et al., 1976). Poor functioning has been reported in individuals with schizotypal personality disorder (Henry et al., 2008, Skodol et al., 2002), schizophrenia (Robertson et al., 2013) and ASD (Engstrom et al., 2003, Kastner et al., 2015). Hence a combined worsening effect may be expected in BD patients with high levels of co-occurring autistic and schizotypal traits. A recent study evaluated the effect of co-occurring autistic and positive schizotypal (i.e. relating to psychotic-like experiences) traits on the ability to appreciate the perspective of others (or mentalising) in the general population (N=201) (Abu-Akel et al., 2015). It showed that while autistic and positive schizotypal traits independently induced perspective-taking errors, their interaction was associated with fewer errors, reflecting an improvement in mentalising abilities. The authors proposed that this unexpected finding may be explained by the diametric model (Crespi and Badcock, 2008), which postulates that ASD and SSD have opposing effects on mentalising abilities, whereby autism is associated with reduced or no mentalising, and schizophrenia with dysfunctional overmentalising. While global functioning is not a test of mentalising per se, it has been shown to be associated with socio-cognitive abilities (Bo et al., 2015) and improve following mentalising-based treatments (Bateman and Fonagy, 2008). To-date, no study has investigated the effect of co-occurring autistic and schizotypal traits on an outcome of clinical value in a psychiatric population.
Thus the present study has two main objectives: (1) to determine the expression of autistic and positive schizotypal traits in a large sample of adults with BD, and (2) to examine whether co-occurring autistic and positive schizotypal traits interact to affect global functioning in this population. The assessment of positive schizotypy only, rather than the general construct of schizotypy (comprising both positive and negative traits), is based on evidence that autistic and schizotypal traits cannot be distinguished by the presence or absence of negative traits, due to similarities in impaired social and communicative functioning (Spek and Wouters, 2010). Moreover, given that ASD is more prevalent in males compared to females (Lehnhardt et al., 2016), the expression of autism traits in our sample was analysed for male and female patients separately.
Investigating the prevalence of autistic and schizotypal traits in BD has management implications for individuals with BD, and may contribute to understanding the aetiology of BD. Moreover, isolating and characterising the expression of autistic and schizotypal traits is important to understanding the nature of their effect on the course, outcome and treatment of the index condition (i.e. BD).
Section snippets
Participants
Participants were recruited by the Bipolar Disorder Research Network (BDRN) to an on-going programme of research into the genetic and non-genetic causes of BD. The study has UK National Health Service (NHS) Research Ethics Committee approval and local Research and Development approval in all participating NHS Trusts/Health Boards. Participants were recruited systematically via NHS mental health services, and non-systematically via advertisements on the BDRN website, in general practitioner
Expression of autistic and positive schizotypal traits
On the AQ-Short, the sample scored a mean of 65.02 (SD=11.51; 95% CI 64.22–65.82). When comparing males and females, the males (Mean±SD=68.66±10.76) scored significantly higher than the females (Mean±SD=63.79±11.50) (tdf=795=5.28, p<0.001, Cohen's d=0.44).
Using the AQ-Short cut-off of >65, 47.2% (95% CI=43.7–50.7%) of the entire sample scored positive for clinically significant levels of autistic traits, 60.20% (95% CI=53.43–66.97%) in males, and 42.79% (95% CI=38.82–46.75%) in females. When
Discussion
This study sought to assess the expression of autistic and positive schizotypal traits in a large, well-characterised, adult sample of BD (N=797), and their concurrent effect on global functioning. Approximately, half of the sample exhibited clinically significant levels of autistic traits, and over a third on applying a more conservative cut-off. This is consistent with the single previous study of autistic-like traits conducted in an adult BD sample, in which half of the participants
Contributors
A.A. and J.K. analysed the data and wrote the study. A.A., L.J., K.G.S. and J.K. designed the study. All authors contributed to and have approved the final manuscript.
Acknowledgements
Many thanks to members of the Bipolar Disorder Research Network and all participants.
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2019, Psychiatry ResearchCitation Excerpt :Matsuo et al. (2015) found a 50% rate of high autistic traits among 56 subjects with BD, as evaluated by means of the SRS scale. More recently, Abu-Akel et al. (2017) reported a 47.2% rate of subjects with significant levels of autistic traits in a sample of 797 BD patients assessed with the AQ short. Despite the use of different psychometric measures, the three studies indicate that up to 50% of BD patients may show a significant level of autistic traits.
The mediating effect of trauma and stressor related symptoms and ruminations on the relationship between autistic traits and mood spectrum
2019, Psychiatry ResearchCitation Excerpt :The relatively high mean score reported on AdAS Spectrum (50.2), with a 25.3% of the sample scoring higher than 65, is in line with previous literature that identifies university students as a group at risk for the presence of AT (Baron-Cohen et al., 2001; Choteau et al., 2016; Dell'Osso et al., 2018c, 2016c; Pisula et al., 2013; Shi et al., 2017; Sierro et al., 2016; Stevenson and Hart, 2017; Trevisan and Birmingham, 2016; Wakabayashi et al., 2006). The association between AT and mood spectrum symptoms has been previously highlighted in several studies conducted in children and adolescents (Kunihira et al., 2006; Pine et al., 2008; Towbin et al., 2005) and, more recently, also in adult populations (Abu-Akel et al., 2017; Liu et al., 2017; Matsuo et al., 2015). In particular, our findings are pretty consistent with those by Kanne and colleagues (2009), who reported that university students with greater levels of AT also have greater psychiatric difficulties across a broad range of psychopathological dimensions, including depression.
Mood symptoms and suicidality across the autism spectrum
2019, Comprehensive PsychiatryCitation Excerpt :Parallel, the ASD group reported significantly higher MOODS-SR total score and MOODS-SR depressive component score than the AT group, and the AT group in turn scored significantly higher than the HC. On one hand, these results confirm previous studies highlighting a strong relationship between MD and both clinical and subthreshold ASD [32–34,38,40,42,55]; on the other hand, our data seem to point towards a further broadening of the link between the two psychopathological dimensions, which is not limited to full-blown ASD and MD manifestations, but also features the wider mood and autism subthreshold spectrums. According to the SCID-5, the overall comorbidity with other mental conditions was higher among the AT group than in the ASD group (57.35% vs 23.52%).
The association of excitation and inhibition signaling with the relative symptom expression of autism and psychosis-proneness: Implications for psychopharmacology
2019, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :However, in considering the relationship between autism and schizophrenia spectrum disorders, two emerging lines of evidence ought also to be considered: (1) that these conditions can co-occur at both the diagnostic and trait levels than would be expected by chance (Chisholm et al., 2015; Larson et al., 2017), and (2) that these conditions are at the opposite extremes of the same cognitive continuum (Abu-Akel and Bailey, 2000; Crespi and Badcock, 2008). In light of these lines of evidence, several investigations have examined the impact that such co-occurrence could have on social cognition and behavior in both healthy (Abu-Akel et al., 2017b; Abu-Akel et al., 2015) and clinical populations (Abu-Akel et al., 2017c; Abu-Akel et al., 2018; Upthegrove et al., 2017). This body of research showed that attentional, socio-cognitive and functional outcome measures are largely interactively modulated by the relative expression of autism vis-à-vis psychosis-proneness.