The Journal of Allergy and Clinical Immunology: In Practice
Original ArticleSkin Prick Test Predictive Values for the Outcome of Cashew Challenges in Children
Section snippets
Study populations
The population cohort of this study comprised participants who underwent cashew OFC as part of the HealthNuts and SchoolNuts studies. The HealthNuts and SchoolNuts studies are 2 large population-based allergy studies performed at the Murdoch Children's Research Institute. Both studies recruited participants from the community. Cashew OFCs were performed at 4-year-old and 6-year-old follow-up in the HealthNuts study, whereas the SchoolNuts study assessed students aged 10 to 14 years. The study
Criteria for undergoing cashew oral food challenges
HealthNuts participants with a cashew SPT ≥1 mm or a parent-reported reaction consistent with an IgE-mediated allergy were invited for a clinic appointment with a specialist allergy nurse and OFC. The low SPT cutoff for sensitization was applied in the HealthNuts study to ensure that all potential cases of food allergy were detected. Cashew OFCs were offered at both the 4-year-old and 6-year-old follow-up.
SchoolNuts participants with a parent-reported history of an adverse food reaction
Statistical Methods
Continuously valued variables are summarized using means (and standard deviations) or medians (and range), with frequencies reported as percentages with 95% confidence intervals (CIs) based on the binomial distribution. A 2-sample comparison of the prevalence of positive OFC within the clinic cohorts showed little evidence that these samples were drawn from populations with different prevalence of cashew allergy (P = .24) and similarly for the population-based cohorts (P = .24). There was also
Ethics
Approval to conduct the HealthNuts study was obtained from the Victorian State Government Office for Children (reference no. CDF/07/492), the Victorian State Government Department of Human Services (reference no. 10/07), and the RCH Human Research Ethics Committee (reference no. 27047). For the SchoolNuts study, ethics approval was obtained from the RCH Human Research Ethics Committee (HREC number 31079), the Department of Education, and Early Childhood and the Catholic Education Office. All
Study populations
Demographic and clinical characteristics stratified by the cashew OFC cohort are outlined in Table I. A total of 386 cashew OFCs were performed in a clinical setting (RCH: n = 343, MACCS: n = 43) and 145 cashew OFCs were performed as part of the population-based studies (HealthNuts: n = 108, SchoolNuts: n = 37). Age stratified demographic and clinical characteristics for the clinic cohort are outlined in Table E2 (available in this article's Online Repository at www.jaci-inpractice.org).
Results of cashew OFC
Among
Discussion
To our knowledge, this is the largest series of OFCs for cashew allergy reported and the first study to report 95% PPVs for cashew SPT. We found the SPT threshold for 95% PPV among a clinic cohort of 14 mm and a population cohort of 10 mm with marked differences in cashew allergy prevalence between the clinic and population cohorts.
The strengths of this study are the large number of cashew OFCs and the development of SPT thresholds with 95% PPVs for cashew allergy using data contributed from
Conclusion
Within a population-based cohort we have established a 95% PPV for cashew SPT of 10 mm. It is known that 95% PPVs can vary depending on the population they are generated from and this study has demonstrated considerable variability between clinic- and population-based cohorts for the 95% PPV for cashew SPT. To improve tree nut allergy diagnosis and management, further work is required using data based on OFC-confirmed outcomes with OFC offered to all sensitized individuals irrespective of wheal
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2022, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Although patients did not undergo a challenge to peanut, rates of lower respiratory symptoms and/or the need for rescue epinephrine due to reactions across the entire FC dosing range were not greater than those reported in the literature for peanut. Finally, we assessed the rate of anaphylaxis to very low (≤upper 95th CI for the ED05)6 levels of allergen consumption at FC to cashew27,29-36 (Table E1, available in this article’s Online Repository at www.jaci-inpractice.org), hazelnut27-31,37-40 (Table E2, available in this article’s Online Repository at www.jaci-inpractice.org), and walnut29,30,41-43 (Table E3, available in this article’s Online Repository at www.jaci-inpractice.org) reported in the literature, and undertook a meta-analysis (Figures E1-E3, available in this article’s Online Repository at www.jaci-inpractice.org). These data are summarized in Table IV.
The Accuracy of Diagnostic Testing in Determining Tree Nut Allergy: A Systematic Review
2021, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Study size ranged from 61 to 531. One study included a large population cohort,15 whereas the others were classified as outpatient (n = 3) or retrospective (n = 1). Clinical accuracy of SPTs to determine cashew and pistachio allergy is good, with the AUCs presented ranging between 0.81 and 0.94 for cashew and between 0.85 and 0.89 for pistachio.14,15,20
Recent advances in the management of nut allergy
2021, World Allergy Organization Journal
This study is supported by funding from the National Health and Medical Research Council (NHMRC) of Australia (HealthNuts study ID 1006215 and SchoolNuts study ID 1047396), the Australian Food Allergy Foundation, the Victorian Government’s Operational Infrastructure Support Program, and the NHMRC Centre for Food and Allergy Research (ID 1041420). K. J. Allen, S. C. Dharmage, A.-L. Ponsonby, L. C. Gurrin, J. J. Koplin and R. L. Peters hold National Health and Medical Research Council (NHMRC) awards. V. McWilliam received a PhD scholarship from the NHMRC-funded Centre for Food Allergy Research (CFAR). K. Perrett holds a Melbourne Children's Clinician Scientist Fellowship.
Conflicts of interest: V. McWilliam reports personal fees from speaker honorariums for Aspen Global, Abbott Australasia, and Nestle Health Sciences and personal fees from an Advisory Panel Consultancy for Nestle and Nutricia outside the submitted work. K. J. Allen was previously on the medical advisory board of Before Brands. M. L. K. Tang is on the Nestle Medical Advisory Board Oceania; is a past member of the Danone Nutricia Global Scientific Advisory Board and Medical Advisory Board ANZ; has received lecture fees from Danone Nutricia, Abbott Australasia, and Nestle; is employed by and holds stock options for Prota Therapeutics; had performed consultancy services for Deerfield Consultancy, GLC Consultancy, and Bayer; and has a patent through MCRI. The rest of the authors declare that they have no relevant conflicts of interest.
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K. J. Allen is no longer affiliated with her declared institution but the study was conducted while she was employed there.
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These authors contributed equally to this work.
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The HealthNuts investigators who are not individually named as authors are Terence Dwyer, MBBS, MD, MPH, Adrian Lowe, PhD, Melissa Wake, MBChB, MD, FRACP, FAHMS, and Colin Robertson, MD. The SchoolNuts investigators who are not individually named as authors are Susan Sawyer, MD, George Patton, MD, PhD, Jo Douglass, MD, and Peter Vuillermin, MBBS, FRACP, PhD.