Journal of the American Medical Directors Association
Muscle Strength, Mass, and Function in Older PersonsOriginal StudySarcopenia Definitions and Their Associations With Mortality in Older Australian Women
Section snippets
Study Population
The population is older community-dwelling individuals that participated in the Perth Longitudinal Study of Aging in Women (n = 1500, PLSAW; http://www.lsaw.com.au). Women were predominantly Caucasian (99.3%) and originally recruited in 1998 to a 5-year, double-blind, randomized controlled trial of daily calcium supplementation to prevent fracture, the Calcium Intake Fracture Outcome Study (CAIFOS).17 The participants from CAIFOS were re-enrolled in 2003 into 2 additional 5-year extension
Results
Baseline characteristics for all participants (n = 903, mean age = 79.9 ± 2.6 years) by the 4 sarcopenia definitions are displayed in Table 1. The proportion of women categorized as presenting with sarcopenia differed substantially by definition (Table 1). When comparing the number of women presenting with sarcopenia, 58 and 191 individuals were captured only by the FNIH and EWGSOP definition, respectively, while 27 were captured by both definitions. When comparing FNIH and AUS-POPF, 85 women
Discussion
The main finding from this prospective cohort study in older Australian women was that sarcopenia was associated with increased relative hazards for all-cause mortality according to the EWGSOP and AUS-POPE definitions. However, no definition compared with age alone improved model discrimination for all-cause mortality over 5 and 9.5 years. Among the 4 sarcopenia definitions tested, AUS-POPE was associated with the highest relative hazard for mortality, especially over shorter follow-up periods
Conclusions/Relevance
In summary, among the 4 definitions presently examined, AUS-POPE (adapted from the EWGSOP) had the strongest association with long-term all-cause mortality risk in older community-dwelling Australian women. As the aforementioned definitions include poor physical function, this finding may be largely explained by the inverse relationship recorded between TUG and mortality. In addition, our results suggest that regional population-specific cut-points (where available) may be applied to the EWGSOP
Acknowledgments
The authors thank the staff at the Western Australia Data Linkage Branch, Hospital Morbidity Data Collection and Registry of Births, Deaths, and Marriages for their work on providing the data for this study. The Perth Longitudinal Study of Aging in Women (PLSAW) was funded by Healthway, the Western Australian Health Promotion Foundation and by project grants 254627, 303169 and 572604 from the National Health and Medical Research Council (NHMRC) of Australia.
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The Perth Longitudinal Study of Ageing in Women (PLSAW) was funded by Healthway, the Western Australian Health Promotion Foundation and by project grants 254627, 303169 and 572604 from the National Health and Medical Research Council (NHMRC) of Australia. The salary of J.M.H. is supported by a NHMRC of Australia Senior Research Fellowship and a Royal Perth Hospital Medical Research Foundation Fellowship. The salary of J.R.L. and D.S are supported by a NHMRC of Australia Career Development Fellowship. None of these funding agencies had any input into any aspect of the design and management of this study.
The authors declare no conflicts of interest.