Journal of Biological Chemistry
Volume 297, Issue 1, July 2021, 100900
Research ArticleHuman and viral membrane–associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression
Under a Creative Commons license
open access
Keywords
membrane-associated E3 ubiquitin ligase
deep mutational scanning
protein–protein interactions
immune regulation
Kaposi's sarcoma virus
membrane protein
Abbreviations
DMS
deep mutational scanning
DOX
doxycycline
HLA
human leukocyte antigen
ICAM-1
intercellular adhesion molecule 1
IRES
internal ribosome entry site
JM
juxtamembrane
KSHV
Kaposi's sarcoma herpesvirus
MARCH
membrane-associated RING-CH
MFI
mean fluorescence intensity
MHC
major histocompatibility complex
MIR
modulator of immune recognition
PolyVal TMD
PolyValine TM domain
TM
transmembrane
TMD
transmembrane domain
UMI
unique molecular identifier
Cited by (0)
Present address for Raphael Trenker: Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA.
© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.