Letter to the EditorAcquisition of the fexA and cfr genes in Staphylococcus pseudintermedius during florfenicol treatment of canine pyoderma
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Funding
This work was funded by the Fundação para a Ciência e a Tecnologia (FCT), through Project PTDC/CVT-EPI/4345/2012 and by PhD grant SFRH/BD/68864/2010 to NC. The work conducted at the Friedrich-Loeffler-Institut (FLI) (Neustadt-Mariensee, Germany) was financially supported by the German Federal Ministry of Education and Research through the German Aerospace Center [grant no. 01KI1301D, MedVet-Staph 2].
Competing interests
None declared.
Ethical approval
Not required.
References (5)
- et al.
Meticillin-resistant Staphylococcus pseudintermedius: clinical challenge and treatment options
Vet Dermatol
(2012) - et al.
Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North America: an international multicentre study
J Antimicrob Chemother
(2010)
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