Short communicationThe case for lamotrigine monitoring in pregnancy
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The influence of dosage, age and comedication on steady state plasma lamotrigine concentrations in children: a prospectice study with preliminary assessment of correlation and clinical response
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Cited by (15)
Seizures and Intracranial Hemorrhage
2013, Obstetrics and Gynecology Clinics of North AmericaCitation Excerpt :Some current published guidelines recommend monitoring anticonvulsant drug levels every trimester and then 1 month after delivery.19,20 For those drugs that are highly or moderately bound, such as phenytoin, phenobarbital, carbamazepine, and sodium valproate, it has been recommended to monitor only the drug-free levels.19,21 Some of the newer anticonvulsants do not have well-established therapeutic ranges, making monitoring difficult.
Gender issues
2012, Handbook of Clinical NeurologyCitation Excerpt :If a woman has been seizure free for the 9 months before pregnancy, she has an 84–92% chance of remaining seizure free through pregnancy (Harden et al., 2009c). AED concentrations, particularly of lamotrigine and oxcarbazepine, should be monitored during pregnancy and AEDs altered accordingly to seizure frequency and plasma levels (Mazzucchelli et al., 2006; Vajda et al., 2006). Hemorrhagic disease of the newborn is more likely to occur in infants whose mothers are taking hepatic microsomal enzyme-inducing AEDs.
The Australian pregnancy register of anti-epileptic drugs: 10 years of progress
2010, Journal of Clinical NeuroscienceCitation Excerpt :The APR was the first to report preliminary observations on second-generation drugs and presented comments on use of lamotrigine in pregnancy, in line with anecdotal clinical observations on difficulties of maintaining seizure control while using this drug in pregnancy. We introduced and discussed the concept of an individual plasma level range for lamotrigine and reported the value of lamotrigine monitoring.14 The US Register will not publish until highly significant data are available, by which time the drug may have been abandoned or significant harm may have resulted.
Smoking reduces serum levels of lamotrigine
2008, SeizureCitation Excerpt :Lamotrigine (LTG) is widely used for the treatment of epilepsies with simple- and complex-partial as well as generalized seizures.1 Many pharmacokinetic effects of other anticonvulsive drugs or other agents (e.g. hormones) on serum levels of LTG have been described.2–4 As influences of smoking on drugs metabolized by glucuronidation such as lorazepam and oxazepam have been reported and LTG is also substrate for glucuronidation,5 an effect on LTG appears to be possible.
Neuroteratogens in man: An overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy
2006, Reproductive Toxicology