Images in Neuroscience: Question
Psychosis and vertical supranuclear opthalmoplegia

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Clinical background

A 31-year-old woman presented with a three month history of increasing agitation, mood lability, disorganised thinking, psychomotor acceleration and the development of delusions of persecution, reference and misidentification. Her family had also noted increasing clumsiness, alterations to her gait and alterations to her speech over 5 years. During this time she had increasing difficulties holding down employment, marked by problems with organization and memory. She had also suffered a number

What is the most likely diagnosis?

  • 1.

    Tay-Sach’s disease.

  • 2.

    Neuroacanthocytosis.

  • 3.

    Niemann-Pick disease type C.

  • 4.

    Chronic schizophrenia.

Answer on pages 370–371.

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