Case ReportSplenic angiosarcoma metastasis to the brain
Introduction
Primary splenic angiosarcoma is very rare. This neoplastic process has a high metastatic rate and dismal prognosis. The literature contains only six cases of disseminated disease with brain metastases, with mean survival of 6.6 months from initial diagnosis,[1], [2] all confirmed on autopsy. To our knowledge, we present the first patient with a cerebral metastasis of a splenic angiosarcoma treated by craniotomy and resection of metastasis.
Section snippets
Case report
A 61-year-old Caucasian woman presented to our neurosurgical unit. The patient was diagnosed with splenic angiosarcoma 5 years prior to presentation and underwent a splenectomy. Six months prior to her first neurosurgical visit, she was found to have pulmonary metastasis, for which she underwent chemotherapy. She also developed right hip pain and a sacral lesion was found. Three months later, she developed blurring of visual acuity and intermittent flashing lights in her left visual field
Discussion
Angiosarcomas are uncommon malignant neoplasms characterized by rapidly proliferating, extensively infiltrating anaplastic cells. They are derived from endothelial cells of arteries, veins or lymphatic channels.3
The macroscopic appearance of splenic angiosarcoma varies from one to several nodular, well-circumscribed masses to large ill-defined regions of haemorrhage and necrosis.2 All angiosarcomas have similar microscopic findings, with vascular spaces more or less obvious and lined by tumour
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Cited by (12)
Metastatic Cardiac Angiosarcoma to the Lung, Spine, and Brain: A Case Report and Review of the Literature
2017, World NeurosurgeryCitation Excerpt :For metastatic CNS angiosarcoma, Shweikeh et al.2 reported an average patient age of 42.3 years with 70% male predominance. Primary sites of disease include the heart, aorta, femur, placenta, spleen, liver, and scalp.7-9,12,13,19,28-39 The most common primary site of angiosarcomas with CNS metastasis is the right atrium of the heart (35% of reported cases).8,9,12,13,29,35,39
Spleen angiosarcoma: a world review
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