Images in Neuroscience: Question

An abnormal electrocardiogram, cerebral calcification and seizures

Clinical background

A 30-year-old man presented to the emergency department after a generalized tonic–clonic seizure. He had suffered a similar seizure 1 year prior, for which no investigations were done. The past history and family history were otherwise unremarkable with no risk factors for epilepsy. The physical examination was normal. Serum biochemistry showed a corrected calcium concentration of 1.19 mmol/L (normal range 2.2–2.6 mmol/L), phosphate concentration of 1.98 mmol/L (normal range 0.8–1.5 mmol/L) and

What is the diagnosis?

• A.

  Toxoplasmosis

• B.

  Cerebral amyloid angiopathy

• C.

  Mitochondrial cytopathy

• D.

  Fahr’s disease

• E.

  Pseudohypoparathyroidism

Answer on page 479.