PathologyLip Cancer: A Clinicopathological Study and Treatment Outcomes in a 25-Year Experience
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Study Design and Sample
To address the research purpose, the authors designed and implemented a retrospective cohort study (approved by the human studies committee, protocol number 2011-01314). This study followed the guidelines of the Declaration of Helsinki. The study population was comprised of all patients presenting for evaluation and treatment of LSCC from January 1989 through December 2013 at the Oral Oncology Center, Araçatuba Dental School, São Paulo State University (UNESP), Brazil.
Patients were included in
Epidemiologic Features
Clinical reports of 144 patients with LSCC were studied. There were 117 men (81.25%) and 27 women (18.75%) whose age ranged from 19 to 98 years (mean, 60.21 yr). The age intervals of younger than 53 years (32.00%), 53 to 65 years (29.80%), 66 to 75 years (17.36%), and older than 75 years (20.84%) were considered for this study, according to age range lip cancer criteria defined by Czerninski et al.5 Analysis of gender with age range showed no statistical differences (P = .0967). One hundred
Discussion
The purpose of this study was to investigate the clinicopathologic profile and treatment outcomes of patients with LSCC treated in a single institution for the past 25 years. Based on the literature and the authors' clinical experience, the study's main hypothesis predicted that clinicopathologic variables would affect treatment outcomes in patients with LSCC. In this retrospective cohort study, most patients with LSCC were men (81.25%), had white ethnicity (93.05%), had the tumor located in
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Conflict of Interest Disclosures: None of the authors have any relevant financial relationship(s) with a commercial interest.