Original ArticlePrediction of Late Death or Disability at Age 5 Years Using a Count of 3 Neonatal Morbidities in Very Low Birth Weight Infants
Section snippets
Methods
Infants with birth weights of 500 to 1250 g were enrolled in the international CAP trial between 1999 and 2004 and followed to a corrected age of 5 years.14, 15, 16 The research ethics boards of all participating clinical centers approved the initial trial protocol and the additional 5-year follow-up. Written informed consent was obtained from a parent or guardian of each infant prior to enrollment and again before the assessments at 5 years. Only infants who survived to 36 weeks PMA were
Results
A total of 2006 infants with birth weights of 500-1250 g were enrolled in the original CAP trial. Four of 35 clinical centers did not participate in the 5-year follow-up. The remaining 31 centers had enrolled 1932 infants, of whom 1853 survived to 36 weeks PMA. All 3 neonatal morbidities—BPD, brain injury, and severe ROP—were known for 1791 CAP trial participants, of whom 1514 children had adequate data for the analysis of the composite outcome of death or disability at 5 years. The
Discussion
This ancillary analysis of CAP trial data for infants with birth weights of 500-1250 g confirmed the independent prognostic effect of BPD, serious brain injury, and severe ROP we previously observed in the Trial of Indomethacin Prophylaxis in Preterms cohort.11 Counting whether infants developed none, any 1, any 2, or all 3 of these neonatal morbidities strongly predicted a late death after 36 weeks PMA or disability at a corrected age of 5 years. Each additional morbidity multiplies the odds
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Funded by the Canadian Institutes of Health Research (MCT-13288). The authors declare no conflicts of interest.
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List of CAP Trial Investigators is available at www.jpeds.com (Appendix).