Original ArticlesBreast Milk Feeding, Brain Development, and Neurocognitive Outcomes: A 7-Year Longitudinal Study in Infants Born at Less Than 30 Weeks' Gestation
Section snippets
Methods
We studied participants in the Victorian Infant Brain Studies longitudinal cohort. Two hundred twenty-four infants born at <30 weeks' gestation or <1250 grams birth weight were enrolled before term equivalent age at the Royal Women's Hospital in Melbourne, Australia between July 2001 and December 2003. Exclusion criteria included congenital anomalies likely to affect brain development or function. Parents provided informed consent for their children to participate.
The Royal Women's Hospital and
Results
Table I shows characteristics of our participants, who had rates of perinatal complications and long-term outcomes typical of their immaturity (mean [SD] gestational age, 27.3 [1.8] weeks) at birth. The mean number of days from day 0-28 on which infants received breast milk as >50% of their feedings was 21 (SD 7). Mean breast milk intake in the first 28 days was 90 mL/kg/d (SD 43). Multiple gestations comprised 45% of the cohort. As compared with singletons, mean breast milk intake for
Discussion
In a contemporary cohort of 180 very preterm infants, we found favorable associations of maternal breast milk intake in the first 28 days of life with neurodevelopmental outcomes at 7 years of age. For example, IQ was 0.5 points higher per additional day that breast milk intake was >50% of total enteral intake, and 0.7 points higher per additional 10 mL/kg/d breast milk ingested. Even if residual confounding explains some of this effect, our results nonetheless suggest a substantial impact of
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Funded by Australia's National Health & Medical Research Council; Centre of Clinical Research Excellence (546519 [to L.D. and P.A.]); Centre of Research Excellence in Newborn Medicine (1060733 [to L.D., P.A., and D.T.]); (237117 [to L.D.]); (491209 [to P.A.]); Senior Research Fellowship (1081288 [to P.A.]); Early Career Fellowships (1012236 [to D.T.] and 1053787 [to J.C.]); Career Development Fellowships (1085754 [to D.T.] and 1053609 [to K.L.]); National Institutes of Health (HD058056); United Cerebral Palsy Foundation (US); Leila Y. Mathers Charitable Foundation (US); the Brown Foundation (US); the Victorian Government's Operational Infrastructure Support Program; and The Royal Children's Hospital Foundation. V.N. was supported by the Cambridge Commonwealth Travelling Bursary (St John's College, Cambridge); Mary Euphrasia Mosley and Sir Bartle Frere Fund; Lord Mayor's 800th Anniversary Awards Trust; Nichol Young Foundation; and the Worts Travelling Scholars' Award. T.I. served on the Editorial Board of The Journal of Pediatrics (2007-2015). The other authors declare no conflicts of interest.